Title : Identification and Characterization of an Acinetobacter baumannii Biofilm - Associated 1 Protein 2 Running Title : A . baumannii biofilm - associated protein 3 Byline :
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Phonotypic Investigation of Biofilm Formation and Determination of Presence of bap and blaOXA-51 Genes in Acinetobacter baumannii From Clinical Specimens in Tehran
Background: Acinetobacter baumannii is a non-fermentative gram-negative coccobacill that has high level of resistance to antimicrobial agents. Biofilm formation is an important feature of most clinical isolates of Acinetobacter spp, this led to higher resistance to antibiotics. The current study aimed to assess the ability of biofilm production and to determine the frequency of bap gene in cl...
متن کاملMolecular Analysis and Expression of bap Gene in Biofilm-Forming Multi-Drug-Resistant Acinetobacter baumannii
Background: Acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. In this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap) in development of biofilm...
متن کاملFrequency of bap and cpaA virulence genes in drug resistant clinical isolates of Acinetobacter baumannii and their role in biofilm formation
Objective(s): Acinetobacter baumannii has a high propensity to form biofilm and frequently causes medical device-related infections with multiple-drug-resistance in hospitals. The aim of this work is to study antimicrobial resistance and the role of bap and cpaA genes in biofilm formation by A. baumannii to understand how this pathogen persists in the hospital environment. Materials and Methods...
متن کاملMolecular Detection of Type II Toxin-Antitoxin Systems and their Association with Antibiotic Resistance and Biofilm Formation in Clinical Acinetobacter baumannii Isolates of Burn Patients
Background and purpose: Burn wounds are a good host for infections. Acinetobacter baumannii is an opportunistic bacterium in patients with burn infections. Toxin-antitoxin systems (TAS) are genetic elements that are essential for antibiotic resistance and biofilm formation in bacteria, including higBA and relBE TA systems. The present study aimed to investigate the frequency of higBA and relBE...
متن کاملMolecular analysis of the Acinetobacter baumannii biofilm - associated 1 protein 2 3
3 H. M. Sharon Goh, Scott A. Beatson, Makrina Totsika, Danilo G. Moriel, Minh-Duy 4 Phan, Jan Szubert, Naomi Runnegar, Hanna E. Sidjabat, David L. Paterson, Graeme R. 5 Nimmo, Jeffrey Lipman and Mark A. Schembri 6 7 Australian Infectious Diseases Research Centre, School of Chemistry and Molecular 8 Biosciences, The University of Queensland, Brisbane QLD 4072, Australia. 9 Pathology Queensland C...
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